Digestive enzymes and probiotics can be used to help relieve heartburn and acid reflux. Enzymes like those in Enzalase help breakdown hard to digest foods which reduces the transit time and helps normalize the digestive process. Probiotics work primarily in the intestinal tract but have a synergistic effect with proton-pump cells in the stomach which produce stomach acid. Better balance of the microbiome in the lower parts of the GI tract leads to better digestion in the higher portions of the digestive system.