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Enzalase® Probiotic Compatible Enzymes

Enzalase® contains twelve plant-based digestive enzymes and is uniquely formulated to emulsify fat and helps breakdown all four major food groups. This helps you digest your food with ease and also releases key nutrients that stimulate your probiotic microflora. Enzalase® helps with digestive comfort and regularity*!

What is Enzalase®?

Enzalase represents a new concept in digestive enzyme supplements; its 12 powerful enzymes are balance-formulated to boost the body's ability to digest all major food types while simultaneously stimulating probiotic bacteria.  Enzalase also sets the standard for enzyme supplements by working for systemic health and colon cleansing as well!

Inside an Enzalse Capsule

  • ENZALASE® The Enzyme Supplement that Reduces Indigestion and Stimulates Probiotics
  • 25% More Capsules (Now 50 Per Bottle) than Before - Still the Same Low Price!
  • We've Added 100% More Lactase Which Helps Digest Lactose Faster and More Completely!
  • Enzalase is the only multi-enzyme supplement you need, its 12 high potency enzymes digest all food groups plus fiber.
  • Enzalase’s acid-proof formulation survives stomach acid and delivers enzymes deep into the intestinal tract (to finish digestion).
  • Enzalase reduces indigestion and gas fast and is recommended by leading doctors such as Russell Blaylock MD.
  • Only one capsule with the largest meal of the day is required for great economy!

As we get older, food begins to move sluggishly through our digestive tract because our body produces fewer digestive enzymes. Bloating, flatulence and a lingering feeling of fullness results. The 12 high potency enzymes in Enzalase work together to prevent indigestion by boosting the body’s digestive power. In addition, Enzalase stimulates probiotics with bifidogenic enzymes that release soluble fiber – active probiotics further reduce indigestion. Compared to other enzyme supplements Enzalase has the highest LIPASE (fat digesting) activity at 6000 FIP units per capsule and, since fat slows down other digestive enzymes, having high lipase is vital to improving total food digestion. All of the enzymes in Enzalase are protected from stomach acid by a buffered biogel that insures their safe delivery into the intestinal tract (Patent Pending).

Digestive Enzymes

Enzalase® contains guaranteed activity levels of the 12 most important digestive enzymes, only FDA approved G.R.A.S. enzymes of plant origin are used. Each Enzalase® capsule contains:

Alpha-amylase5,000 SKB
Alpha-Galactosidase165 GalU
Bromelain Protease150 GDU
Cellulase3,000 CU
Glucoamylase5 AG
Hemicellulase6,400 HCU
Invertase400 SU
Lactase1000 ALU
LIPASE6,000 FIP Lipase Units
Neutral Protease5,800 HU
Papain Protease42,500 TU
Pectinase7,500 AJDU

Due to the potency of Enzalase® only one capsule per meal is required. Enzalase® is supplied in amber glass bottles containing 50 size "0" Vcaps.

Probiotic Stimulation

Enzalase® stimulates probiotic bacteria in two ways: 1) Its high strength lipase, protease, and carbohydrase enzymes work on food to produce cobiotics (fatty acids, amino acids, and simple sugars) that feed Lactobacillus probiotics in the small intestine and 2) Its high strength fiber digesting cellulase, hemicellulase and pectinase enzymes work to separate soluble fiber prebiotics from insoluble fiber (both types are found in fruits, grains and vegetables) so these important prebiotics can more effectively feed Bifidobacterium probiotics in the large intestine. All of this happens inside you when you take one (1) high potency Enzalase® capsule before a meal. Enzalase® boosts the effectiveness of probiotics and it can make the difference between probiotics working versus not working for many people (Patent Pending).

Enzalase® has been designed to work best with Theralac® brand probiotics. Visit Theralac to read about Theralac®.

Acid-Proof Formulation

Many digestive enzymes are denatured by stomach acid and lose significant strength before they reach the small intestine; lactase, invertase and lipase are examples of acid sensitive enzymes (see Scientific References to read more). Enzalase® is produced by a unique process that allows an acid resistant gel to form around the enzymes in the stomach but dissolves in the small intestine releasing them unharmed, insuring the enzymes are active in the intestinal tract (Patent Pending).

High LIPASE Activity

Enzalase® contains 6,000 FIP units of lipase activity, the enzyme responsible for fat digestion. Strong lipase activity enhances the effectiveness of the other digestive enzymes in Enzalase® by removing fat from the chyme (food mixture) when it leaves the stomach and enters the small intestine. Fat free chyme is a more available substrate for the protein and carbohydrate digesting enzymes and increases their effective activity. Lipase is a very expensive enzyme: Compare the lipase content of Enzalase® with that of competitive enzymes supplements, the difference is dramatic.

ENZASTIM®

EnzaStim® is a unique food grade fat-emulsifier only found in Enzalase® (US Patent 8066986). When the chyme enters the small intestine in depends on the presence of adequate amounts of bile to insure that fats get emulsified. Fats must be emulsified to be digested by lipase. EnzaStim® provides important insurance that this happens.

What’s inside an Enzalase® capsule?

Twelve Digestive Enzymes:

  • Alpha-Amylase - 5,000 SKB
  • Alpha-Galactosidase - 165 GALU
  • Bromelain Protease - 200 GDU
  • Cellulase - 3,000 CU
  • Glucoamylase - 5 AG
  • Hemicellulase - 6,400 HCU
  • Invertase - 400 SU
  • Lactase - 1,00 ALU
  • Lipase - 6,000 FIP (Lipase Units)
  • Neutral Protease - 7,400 HUT
  • Papain Protease - 42,500 TU
  • Pectinase - 25 Endo-PG (7,500 AJDU)

Other ingredients in Enzalase®:

  • Cellulose – Food grade plant cellulose is used to standardize the enzymatic strength of Enzalase®.
  • Sodium Alginate – Provides protection from stomach acid and is a preferred source of prebiotic fiber (Protected by 2 US Patents)[1].
  • HPMC hydroxypropyl methylcellulose – A derivative of plant cellulose which comprises the capsules.
  • Silica – Present to reduce moisture and improve shelf life. Silica, or silicon dioxide, is a micronutrient in human nutrition; a food grade source is used in Enzalase®.
  • EnzaStim® Sunflower lecithin and Oleic Acid – Boosts the fat-digesting activity of Lipase (Protected by a US Patent)[2].
  • Magnesium Stearate – It is used to fill the capsules and ensures a uniform mixture of all ingredients. A pharmaceutical grade, vegetable source is used in Enzalase®. Magnesium Stearate has been safely used in capsules and tablets for over 75 years.

Allergy Statement

Enzalase® contains no: milk, eggs, gluten, wheat, soy, casein, nuts, seafood, or beef products.

[1] US Patents #7,122,370; 7,229,818
[2] US Patent #8,066,986

Dosage Recommendations for Enzalase®

Dose Program #1 - For Improved Digestion

  • Improves Digestion of:
    • Protein
    • Fat
    • Carbohydrate
    • Fiber
  • Take one capsule Acid Proof Image with each meal.
  • One bottle of 50 capsules lasts for 50 meals.

NOTE: Due to Enzalase's high potency and acid-proof delivery, one capsule per meal is usually enough; up to 2 capsules can be taken per meal.

Dose Program #2 - For Probiotic Stimulation

  • Take one capsule Acid Proof Image with a meal four times per week. Meals with two or more different vegetables give best results.
  • One bottle of 50 capsules lasts over 12 weeks.

NOTE: Program #1 provides probiotic stimulation and eliminates the need for Program #2.

Dose Program #3 - For Systemic Health (General Health)

  • Take one capsule Acid Proof Image on an empty stomach with a full glass of water four times per week.
  • One bottle of 50 capsules lasts over 12 weeks.

NOTE: Programs #1 or #2 do not substitute for this program. This program can be taken simultaneously with Programs #1 or #2.

Questions About Enzalase®?

We've compiled a list of questions that are commonly asked about Enzalase®. For general questions, please refer to our Frequently Asked Questions page or, if you can't find what you're looking for, contact us directly.

If you experience indigestion and bloating after a meal, or if food seems to “hang” in your stomach, you will benefit from taking an enzyme supplement. Irregular bowel habits including constipation and diarrhea can also signal a need for enzyme supplementation. If you have such symptoms on a regular basis check with your doctor before taking any supplement.

Most people over 40 can benefit from taking an enzyme supplement for improved digestion but it may not be necessary to take one with every meal. Heavy meals, late dining, spicy meals and meals containing foods not normally eaten are candidates for enzyme supplementation. People over 50 often require an enzyme supplement with lighter meals as well.

Some will. To be of benefit to probiotics, an enzyme supplement must have strong concentrations (high activity units) of fiber digesting enzymes like cellulase, hemicellulase and pectinase. These enzymes release prebiotic sugars and soluble fibers from vegetables and grains. Once free these prebiotics feed the probiotics so they work better. Enzalase® is a new multi-enzyme supplement that contains high levels of prebiotic releasing enzymes.

Yes, when you see FOS (a soluble fiber that feeds certain probiotics) declared as a food ingredient, it’s there as a synthetic compound. When Enzalase® releases FOS from vegetables and grains it’s present with other natural compounds that reduce intestinal gas (which can be significant when synthetic FOS is consumed).

The alpha-galactosidase enzyme in Enzalase® helps reduce gas produced by intestinal bacteria when raffinose family sugars, present in cabbage, broccoli, beans and other vegetables, are consumed.

The lactase enzyme in Enzalase® splits lactose (milk sugar) into two simple sugars, glucose and galactose, which are readily absorbed in the intestinal tract. This helps prevent lactose from reaching the colon where anaerobic bacteria consume it producing gas and discomfort.

By improving digestibility of major food types, proteins, fats and carbohydrates, ENZALASE’s potent enzyme groups (see the above illustration: What’s Inside an Enzalase® Capsule) help free other nutrients such as vitamins and minerals bound within these foods. Once free they can be absorbed by the small intestine and utilized by the body. For example, much of the magnesium in a steak is bound within muscle tissue, digest the muscle tissue and out comes the Mg.

Enzalase® also benefits general health by other mechanisms, when taken between meals, as indicated for the SYSTEMIC HEALTH program in this brochure, the protease and lipase enzymes may help encourage circulation. See Scientific References for more information.

No. Many enzymes are sensitive to stomach acid and lose activity when held at a pH below 2.5 for an hour or more (typical time spent in the stomach). Lactase, for example, can lose 25% or more of its activity under these conditions, lipase even more. So protection from stomach acid is important and the gel-matrix formula used to Acid-Proof® Enzalase® (patent pending) is a vital requirement to get full potency (declared enzyme activity units) through into the small intestine.

Lipase is the enzyme that digests food fats that coat the food mixture (chyme) when it enters the duodenum portion of the small intestine. If you don’t get the fat off the food particles other enzymes can’t function effectively since fat interferes with their ability to attach to there substrates. For example, alpha-amylase can’t effectively attach to starch (its substrate) and digest it if fat is in the way. Enzalase®, with 6,000 FIP lipase units/capsule, is effective at digesting fat so other enzymes can function better.

EnzaStim® is a unique emulsifier (polysorbate 80 on silica – patent pending) that helps the lipase in Enzalase® digest fat more effectively. Fat needs to be emulsified (mixed with water) before it can be digested. The body produces bile for this purpose but not always on schedule or in the necessary amounts. EnzaStim® provides insurance that emulsification occurs.

This was quite a fortuitous discovery. The gel-matrix that gives Enzalase® its Acid-Proof® protection in the stomach does not completely dissolve in the front part of the small intestine but holds together, with much of its enzyme activity tagging along, until it reaches deep into the intestinal tract. Here, for the first time with an enzyme supplement, a portion of the enzymes deep release and offer a deep digestion response. This is particularly important for the prebiotic release enzymes, the pectinase, cellulase and hemicellulase, as they do better in the lower G.I. tract where peristaltic activity (intestinal motility) is slower.

Yes, but its best to separate them by 2-3 hours.

The #1 Probiotic is Theralac® see more about Theralac.

All enzymes, like probiotics, are perishable. Typically, enzymes lose 1% of their strength per month. This can jump to 2-5% under elevated temperatures and high humidity. Most enzyme companies will not tell you this. It’s okay to hold Enzalase® at room temperature for up to three months due to its Totally Inert Packaging (TIP Packaging®) in amber glass bottles with moisture and oxygen absorption packets. Store Enzalase® under refrigeration when at home to insure potency through the expiration date.

By FDA definition, the enzymes in Enzalase® are foods and are all generally recognized as safe (G.R.A.S.). Our recommendation is not to exceed 6 capsules per day. Due to its potency, rarely does one need to use more than one capsule per meal (or one capsule daily for probiotic stimulation).

Generally not, but some prescription drugs do react with enzymes and others may have their action enhanced by enzymes. Always check with your doctor and pharmacist regarding these possible interactions before starting on an enzyme supplement.

The two most common effects reported are:

  1. Improved digestion and greater intestinal comfort after a meal.
  2. Improved regularity with reduced bloating and intestinal gas.

After 1-2 months a noticeable increase in energy and general well being is often reported as well.

Scientific References on Enzalase's® Digestive Enzymes

  1. Haq SK, Rasheedi R, Khan RH (2002) Characterization of a partially folded intermediate of stem bromelain at low pH. Eur J Biochem. 269: 47-52.
  2. Klein G, Kullich W (2000) Short-term treatment of painful osteoarthritis of the knee with oral enzymes. Clin Drug Invest. 19 (1): 15-23.
  3. Brakebusch M, Wintergerst U, Petropoulou T, Notheis G, Husfeld L, et al. (2001) Bromelain is an accelerator of phagocytosis, respiratory burst and killing of Candida albicans by human granulocytes and monocytes. Eur J Med Res. 6 (5): 193-200.
  4. Dresser L, Rehberger A, Kokron E, Paukovits W (1994) Proteolytic enzymes and amylase induce cytokine production in human peripheral blood mononuclear cells in vitro. Cancer Biother. 9 (3): 253-63.
  5. Kleine MW, Stauder GM, Beese EW (1995) The intestinal absorption of orally administered hydrolytic enzymes and their effects in the treatment of acute herpes zoster as compared with those of oral acyclovir therapy. Phytomedicine. 2 (1): 7-15.
  6. Taussig SJ, Szakerczes J, Batkin S ((1985) Inhibition of tumor growth in vitro by bromelain, an extract of the pineapple plant (Ananas comosus). Planta Med. 6: 538-539.
  7. Gamer, MLG (1988) Gastrointestinal absorption of intact proteins. Ann Rev Nutr. 8: 329-350.
  8. Boyne PSMH (1967) Oral anti-inflammatory enzyme therapy in injuries in professional footballers. Practitioner 198: 543.
  9. Cichoke AJ, L Marty (1981) The use of proteolytic enzymes with soft tissue athletic injuries. Am Chirop. 32.
  10. Dietrich RE (1965) Oral proteolytic enzymes in the treatment of athletic injuries: a double-blind study. Penn Med J. 68: 35.
  11. Donelly PK (1983) The role of protease in immunoregulation. British J of Surgery. 70: 614-622.
  12. Hall DA (1982) The effect of enzyme therapy on plasma lipid levels in the elderly. Atherosclerosis. 49: 209.
  13. Gebauer F, Micheel B, et al. (1997) Proteolytic enzymes modulate the adhesion molecule CD44 on malignant cells in vitro. Int J Immunotherapy XIII (3/4): 111-119.
  14. Seifert J, Siebrecht P, et al. (1986) Amylase absorption and transport via blood and lymph after oral administration. Digest Biol Sci 41: 1593.
  15. Batkin S, Taussig SJ, Szekerezes J (1988) Antimetastatic effect of bromelain with or without its proteolytic and anticoagulant activity. J Cancer Res Clin Oncol. 114: 507-508.
  16. Metzig C, et al. (1999) Bromelain proteases reduce human platlet aggregration in vitro. In Vivo. 13: 7-12.
  17. Taussig SJ, Batkin S (1988) Bromelain, the enzyme complex of pineapple and its clinical application. J Ethnopharmcol. 22:191-203.
  18. Izaka K, Yamada M, et al. (1972) Gastrointestinal absorption and anti-inflammatory effect of bromelain. Jpn J Pharmacol. 22: 519-534.
  19. Cichoke AJ (1995) The effect of systemic enzyme therapy on cancer cells and the immune system. Townsend Letter for Doctors and Patients. Nov. 1995: 30-32.
  20. Hingorani K (1968) Oral enzyme therapy in severe back pain. Br J Clin Pract. May 1968, 22 (5): 209-10.
  21. Kelly GS, (1996) Bromelain: A literature review and discussion of its therapeutic applications. Alternative Medicine Review (Nov 1, 1996).
  22. Miller JM, Opher AW (1964) The increased proteolytic activity of human blood serum after oral administration of bromelain. Exp Med Surg. 22: 277-280.
  23. Innerfield I, Wernick T (1961) Plasma anti-thrombin alterations following oral papain. Proc Ext Biol Med. 107: 505-506.
  24. Thacker PA, Campbell GL, GrootWassink J (1991) The effect of enzyme supplementation on the nutritive value of rye-based diets for swine. Can J Anim Sci, 71: 489-96.
  25. Laider B, Letourneur M (1993) Enzymatic debridement of leg ulcers using papain. Annal de Dermatol et de Venereologie. 120(3): 248.
  26. Gardner MLG (1988) Gastrointestinal absorption of intact proteins. Ann Rev Nutr. 8:329-350.
  27. Quigley EM, Hurley D (2000) Autism and the gastrointestinal tract. Am J Gastroenterology 95: 2154-2156.
  28. Molis C, Flourie B, et al (1996) Digestion. excretion, and energy value of fructooligosaccharides in healthy humans. Am J Clin Nutr. 64: 324-8.
  29. Alles MS, Hautvast JGAJ, et al. (1996) Fate of fructooligosaccharides in the human intestine. Br J Nutr. 76: 211-21.
  30. Stone-Dorshow T, Levitt MD (1987) Gaseous response to indigestion of a poorly absorbed fructooligosaccharide sweetner. Am J Clin Nutr. 46: 61-5.
  31. Baumhackl C, Fordermair S (1990) Enzyme therapy in multiple sclerosis. Gen Medicine. 19 (4): 169-172.
  32. Goldberg DM (1992) Enzymes as agents for the treatment of disease. Clin Chimi Acta. 206: 45-76.
  33. Gotze H, Rothman SS (1979) Amylase transport across ileal epithelium in vitro. Gastroenterol. Clin Biol. 3: 298.
  34. Gotze H, Rothman SS (1975) Enteropancreatic circulation of digestive enzymes. Nature 257: 607.
  35. Inderst R (1992) Systemic enzyme therapy. J of Pharmacy. 52.
  36. Inderst R (1990) Enzyme therapy in vascular diseases. Gen Medicine. 19 (4): 154-157.
  37. Lotz-Winter H (1990) On the pharmacology of bromelain, an update with special regard to animal studies on dose-dependent effects. Planta Med. 56: 56-249.
  38. Karani S, Kabaria MS, Barber AE (1971) A double-blind clinical trial with a digestive enzyme product. Br J Clin Pract. Aug 1971: 25 (8): 375-7.
  39. Rothman S, Liebow C, Isenman L (2002) Conservation of digestive enzymes. Physiological Reviews. Jan. 2002, 82 (1): 1-18. Review.
  40. Schneeman BO, Gallaher D (1985) Effects of dietary fiber on digestive enzyme activity and bile acids in the small intestine. Proc Soc for Exp Biol and Med. Soc for Exp Biol and Med (New York) Dec. 1985, 180 (3): 409-14.
  41. Rothman SS, Grendell JH (1983) The case of disappearing pancreatic digestive enzymes. Gastroenterology. Dec 1983, 85 (6): 1438-42.
  42. Jager H (1990) Hydrolytic enzymes in the treatment of HIV infections. Allgemeinmedizin 19: 160-164.
  43. Kleine M W, Ertl D (1997) Introduction to oral enzyme therapy and its use in Varicella zoster treatment. Int J Tiss Reac XIX (1/2) – abstracts of 7th intersci world conf on inflammation, antirheumatics, analgesics, immunomodulators, May 19-21, 1997, Geneva, Switzerland.
  44. Donelly PK (1983) The role of protease in immunoregulation. Brit J of Surgery. 70: 614-22.
  45. Guggenbichler JP (1988) Influence of hydrolytic enzymes in thrombi formation and thrombolysis. Medical World (Med Welt.) 39: 227.

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